Antiviral Effect of Orally Administered ( )- -D-2-Aminopurine Dioxolane in Woodchucks with Chronic Woodchuck Hepatitis Virus Infection
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چکیده
Published Ahead of Print 2 July 2007. 10.1128/AAC.00325-07. 2007, 51(9):3177. DOI: Antimicrob. Agents Chemother. Bud C. Tennant Schinazi, Chung K. Chu, Paul J. Cote, John L. Gerin and F. D. Butler, Andrea L. George, Selwyn J. Hurwitz, Raymond Stephan Menne, Ghazia Asif, Jannan Narayanasamy, Scott Hepatitis Virus Infection Woodchucks with Chronic Woodchuck -d-2-Aminopurine Dioxolane in β )− Antiviral Effect of Orally Administered (
منابع مشابه
Antiviral effect of orally administered (-)-beta-D-2-aminopurine dioxolane in woodchucks with chronic woodchuck hepatitis virus infection.
(-)-beta-D-2-Aminopurine dioxolane (APD) is a nucleoside prodrug that is efficiently converted to 9-(beta-D-1,3-dioxolan-4-yl)guanine (DXG). DXG has antiviral activity in vitro against hepatitis B virus (HBV) but limited aqueous solubility, making it difficult to administer orally to HBV-infected individuals. APD is more water soluble than DXG and represents a promising prodrug for the delivery...
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